Effects of Kampo Medicines on P-Glycoprotein
نویسندگان
چکیده
منابع مشابه
Inhibitory effects of furanocoumarin derivatives in Kampo extract medicines on P-glycoprotein at the blood-brain barrier.
Furanocoumarin derivatives, known as components of grapefruit juice, showing inhibitory effects against P-glycoprotein (P-gp) in the intestine are also contained in the plants of rutaceae and umbelliferae families, which are used as components of Kampo extract medicines. In this study, we investigated the inhibitory effects of byakangelicol and rivulobirin A, known as furanocoumarins showing P-...
متن کاملFuranocoumarin derivatives in Kampo extract medicines inhibit cytochrome P450 3A4 and/or P-glycoprotein
Furanocoumarins in grapefruit are known to show inhibitory effects against P-glycoprotein and/or CYP3A4 in intestinal epithelial cells; however, furanocoumarin derivatives are widely contained in the plants of rutaceae and umbelliferae families, which are used as components of Kampo extract medicines. In this study, we investigated the inhibitory effects of 12 furanocoumarins extracted from pla...
متن کاملFuranocoumarin derivatives in Kampo extract medicines inhibit cytochrome P450 3A4 and P-glycoprotein.
Furanocoumarins in grapefruit are known to show inhibitory effects against P-glycoprotein (P-gp) and CYP3A4 in intestinal epithelial cells; however, furanocoumarin derivatives are widely contained in the plants of Rutaceae and Umbelliferae families, which are used as components of Kampo extract medicines. In this study, we investigated the inhibitory effects of 12 furanocoumarins extracted from...
متن کاملEffects of Clinically Available Blended Herbal Medicines (Kampo Extracts) on the Phosphodiesterase Activity in Rat Hearts
We examined the effects of clinically available Kampo medicines; Kakkon-to (Formula puerariae), Boi-ogi-to (Formula astragali et sinomenii), Chorei-to (Formula polypori) and Tsu-do-san (Pulvis purgtionis sanguinolentiae), on phosphodiesterase (PDE) activity in the rat heart. PDE activity was estimated by measuring the cyclic AMP hydrolyzing speed using the enzymatic fluorometric assay technique...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2009
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.32.2018